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Influenza vaccine (live) | Drugs | BNF | NICE

LAIV induces local inflammation in the nose , with upregulation of B‐ and T‐cell genes and Tfh cells in the draining tonsillar tissue 6-7 days after vaccination [43, 44]. LAIV induces better T fh cell responses in the tonsils and systemic antibody responses in children with lower local salivary IgA levels . LAIV induces ...

Intranasal powder live attenuated influenza vaccine is ... - Nature

Summary of Data Reviewed. Review of LAIV effectiveness data for previous seasons in the United States confirms low to no significant effectiveness of LAIV against influenza A (H1N1)pdm09-like viruses. However, LAIV was generally effective against influenza B viruses and was of similar effectiveness to IIV against influenza A (H3N2) viruses.

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Using a mouse-adapted LAIV against influenza A (H3N2) virus carrying the same mutations as the human FluMist vaccine, we find that LAIV vaccination reverses normal bacterial clearance from the nasopharynx and significantly increases bacterial carriage densities of the clinically important bacterial pathogens Streptococcus pneumoniae (serotypes 1...

Seasonal Effectiveness of Live Attenuated and Inactivated ... - PubMed

Background. Scant evidence exists on the real-world effectiveness of quadrivalent live attenuated influenza vaccines (LAIV-4) in younger children. We aimed to assess the real-world effectiveness of LAIV-4 against influenza-related hospital contacts and admission and morbidity. Methods.